A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
نویسندگان
چکیده
منابع مشابه
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Recently thioredoxin reductase 1 (TrxR1), encoded by Txnrd1, was suggested to modulate glucose and lipid metabolism in mice. Here we discovered that TrxR1 suppresses insulin responsiveness, anabolic metabolism and adipocyte differentiation. Immortalized mouse embryonic fibroblasts (MEFs) lacking Txnrd1 (Txnrd1(-/-)) displayed increased metabolic flux, glycogen storage, lipogenesis and adipogene...
متن کاملGlycolysis and Lipogenesis in the Livers from Children with Type I of Glycogen Storage Disease.
The contents of glycogen and fat and the activities of glucose-6-phosphatase (G6Pase), glucose-6-phosphate dehydrogenase (G6PD), glycolysis and lipogenesis were investigated in the livers from three patients with Type I of glycogen storage disease. The contents of glycogen and fat were markedly increased. The activity of G6Pase was definitely low and that of G6PD was normal or slightly increase...
متن کاملThe dietary management of hepatic glycogen storage disease.
The dietary management of hepatic glycogen storage disease (GSD) is based on an understanding of the primary biochemical abnormalities. Plasma glucose levels are maintained by the release of glucose from the liver. The glucose is formed either by the breakdown of glycogen or it is synthesized from substrates such as fructose, galactose, glycerol or amino acids. The final common step in all thes...
متن کاملGlycogen" A Metabolic
Glycogen was first isolated from liver by Claude Bernard and was assigned a metabolic role--the supply of some glucose to the bloodstream (Bernard, 1857). This function of liver glycogen was confirmed in the first part of this century and was extended, notably by the Coris, to describe the essential role of the liver in the maintenance of blood glucose levels and the tolerance of the extensive ...
متن کاملFatty acid metabolism and hepatic lipogenesis.
The conversion of octanoate-l-Cl4 to radioacetoacetate and the effect of pyruvate on this process are dependent on the K+ concentration in the incubation medium (1). These results prompted this investigation in which the incorporation of octanoate-l-Cl4 into fatty acids and cholesterol was determined in the presence of non-radioactive additions of pyruvate, succinate, and fumarate. Malonate was...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2013
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2013.05.028